I've said it before, and in case you missed it: I love my modifier macros. I have a Roccat Kone mouse, and have the two buttons near my thumb bound as alt and ctrl. This is what my standard macro looks like:
#showtooltip
/startattack
/cast [nomodifier] Spell
/cast [mod:alt] Spell
/cast [mod:ctrl] Spell
/cast [mod:shift] Spell
Which gives me 4 binds per key. I love focus macros and am trying to get used to mouseover macros.